• The first form of life on Earth would have been stimulated by; o High/Low pressure o Varying level of atmospheric gases o High/low Temperatures o Light/Dark (UV/IR radiation) o Wet/Dry o Acidity/Alkalinity o Varying level of Salinity
• The first form of life on Earth would have needed a balancing mechanism to cope with all these parameters - a small molecule immunomodulator
• All life today has this vital small molecule balancing mechanism
• Based on this vital balancing mechanism we have discovered 3,000 genes (~10% of the human genome) with the ability to switch on/off to control the balance
• We have also discovered potential sources of genetic material for each of these 3,000 gene
These results were very exciting, which justified further research. Bearing in mind homeostasis is essential to maintain a balanced body/brain and an immune response system vital to correct occurrences of mutations, diseases, and disorders.
The latest 19 drugs approved by the FDA in December 2021
Like last year, the latest FDA approved drugs for market have increased association with WxGenes, an average of 74%, 5 with 100% plus 9>80% shows the importance of WxGenes.
We believe the non-WxGenes found associated with the diseases are mutations which cause the diseases, and WxGenes are the diseases immune response genes. Diseases are caused by mutations out of control due to their immune response genes being unable to repair. Through better understanding of WxGenes and Non-WxGenes drug developers will be in a stronger position to develop more efficacious drugs.
With the average percentage of WxGenes of the top 50 selling drugs at 64.7% and the average percentage of newest drugs to be approved by the FDA at 76.4% perhaps shows pharmaceutical companies are getting nearer to understanding the importance of WxGenes.
It is becoming increasingly obvious WxGenes are highly important for the development of new drugs. And the new and up and coming Gene and Cell Therapies.
Why is Chines food healthy? Why does Chinese medicine work?
First we looked at a few staples of Chinese foods. Apart from rice and noodles the rest showed an above average of WxGenes.
A further study looked at WxGenes associations with 182 plants (leaves, bark, tubers, oil extracts etc) used in Chinese Medicine.
Results from the analysis of 182 plants used in Chinese Medicine were beyond expectation, showing the percentage of total WxGenes had an average of 82.5% with 66 plants having 100% and 117 plants > than 80%.
This shows the significance of Chinese medicine and also a source for specific genes to be used in future drug development..
Fruits, Vegetables, Herbs, Spices, Meats & Seafoods vs WxGenes
59 Fruits & Vegetables
45 Herbs & Spices
20 Meats & Seafoods
When we analysed Chinese food products and fruit & vegetables, we noticed about 25 important genes missing, compared to metabolism, growth, homeostasis, and immune response. When we analysed meat & seafood, we found all 25 genes. We suggest, as we have evolved as omnivores it is important to recognise a balanced diet including both meat and seafood, is vital for maintaining good health.
Analysis of WxGenes shows there is a very strong association with metabolism, growth, homeostasis, immune response, and plants used in Chinese medicines. Drugs used to treat diseases show consistently (apart from Diarrhoeal disease) higher percentages of WxGenes than the diseases themselves. The Pharma top 50 shows an average percentage of WxGenes of 64.7% and newer drugs have increased associations with WxGenes to 76.4%.
We believe WxGenes are important in the development of new, more efficacious drugs to treat diseases. Our research of plants used in Chinese medicines show where specific genetic materials can be sourced.
With gene-readers becoming more accessible, it opens up the possibility of having individual genome analysis and then using missing WxGenes and therapy to combat genetic mutations, diseases, and disorders.
Using the latest research papers, journal articles, and on-line discussions in blogs, gene arrays for the twelve major components of the small compound are updated twice a year, producing the latest array of WxGenes. Oct2022 was interesting by increasing the number of WxGenes from about 1,000 to 2,699 which is ~10% of the human genes (26,000 - 30,000).
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